Once the flea population is controlled you will be less likely to see fleas. Its safe to say, the information we received will be priceless to many pet parents out there. Revolution has been tested safe in over 100 different pure and mixed breeds of healthy dogs and over 15 different pure and mixed breeds of healthy cats, including pregnant and lactating females, breeding males and females, puppies six weeks of age and older, kittens eight weeks of age and older, and avermectin-sensitive collies. Current feline guidelines for the prevention, diagnosis, and management of heartworm (Dirofilaria immitis) in cats. I do believe the people at the vet's office honestly believe that Revolution is a safer alternative. Revolution (selamectin) is a simple monthly topical medication demonstrated safe to protect your dog or cat from heartworm disease, fleas, and ear mites. zoetisus.com/products/cats/revolution-plus. and control of hookworms, However, avermectins, including selamectin, do bind GABA. Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene. I see fleas on my dog or cat. Members of the avermectin groupsuch as ivermectin, eprinomectin, and doramectin, as well as selamectinare structurally related. Revolution is administered via a spot-on applicator. In dogs, seizures and incoordination have been rarely reported. Cats are also notoriously difficult to medicate (whether via oral or topical route), and many owners may balk at the idea of a regularly scheduled medication administration date with their cat. In cats, lufenuron is dosed at 15 mg per pound (30 mg/kg) once a month or 5 mg per pound (10 mg/kg) injectable every six months. Look, expired products mean their efficacy no longer exists, right? . 15. The topical treatment is formulated to penetrate the skin and enter the bloodstream to provide systemic protection for one month. When used in cats, parasites treated by selamectin include fleas, heartworms, ear mites, hookworms, and roundworms, with some possible effectiveness against ear mites. We comply with the HONcode standard for trustworthy health information. In controlled laboratory studies >98% of fleas were killed within 36 hours. Although this drug is usually administered topically, it can also be administered by injection or by oral tablet, and it works by paralyzing the nervous system of the parasite. If your cat is older than six months of age, your veterinarian may decide to test him/her for heartworm disease before prescribing Revolution. Freedom of Information Summary: Original Abbreviated New Animal Drug Application: SENERGY (selamectin). Washington State University Veterinary Clinical Pharmacology Laboratory. Great holiday, house a bit old and dirty but otherwise ok. When used in dogs, parasites treated by selamectin include fleas, heartworms, ear mites, scabies, and certain ticks. So why make them come in again for a "fresh" round? Generally, nothing will happen. Are Your Expired Medications Still Good? If you receive a package that has an expiration date, please call our team of experts as well as Amazon as this may be a counterfeit product. But there is some risk in taking a heart rhythm medication that, if ineffective, could lead to an unstable and dangerous heart problem. It may take up to 5 days to kill the majority of ticks on your dog. Vet Parasitol. Log in 24/7 to access your pets health care information. 13. 8. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution must be given within a month of the last dose of the former medication. Set up your myVCA account today. Don't be a douche. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. It is a monosaccharide oxime derivative of doramectin, and structurally related to ivermectin. It is exposure to light and air that decrease the . This is understandable. See TABLE 1 for a summary of the labeled indications for selamectin in dogs and cats. Immature stages of the flea called pupae may be present in your pets' environment (yard, flooring, carpet, bedding, etc.). Other side effects reported in cats and dogs include vomiting, diarrhea with or without blood, anorexia (decreased appetite), lethargy (sluggishness), salivation, rapid breathing, pruritus (itching), urticaria (welts, hives), erythema (skin redness), ataxia (incoordination), fever and rare instances of death. Conservative because it is determined by subjecting the . Revolution is not for use in humans. The safety of Revolution administered orally also was tested in case of accidental oral ingestion. It's basically a one-stop shop for parasite management, which is why we believe that it's the best overall flea treatment for cats. Like all medicines, Revolution has some side effects. 5-in-1 Protection for Cats: Fleas, Heartworms, Roundworms, Hookworms and Ear Mites. The efficacy of a topical formulation of selamectin plus sarolaner in preventing the development of a macrocyclic lactone-resistant strain of Dirofilaria immitis in cats. Thanks in advance! Feline heartworm disease is more difficult to diagnose than canine heartworm disease, and clinical signs in cats may be mistaken for respiratory or gastrointestinal disease.20 While topical selamectin shields cats and dogs from heartworm disease caused by Dirofilaria immitis, there is mounting evidence that there are populations of D immitis resistant to conventional macrocyclic lactones in dogs.21 The role of macrocyclic lactone resistance and the relationship to D immitis are relatively unknown in cats.21 Using an experimentally formulated combination of topical selamectin and sarolaner, researchers employed by Zoetis assessed the efficacy of various dosing regimens against a macrocyclic lactoneresistant strain of D immitis. JAVMA. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. After all, the drug manufacturers are required to test the safety and efficacy of their drugs under warm, humid environments (read: bathroom) for years beyond their manufacturing date. 7. Textbooks and formularies may advocate particular products for flea control in rabbits; however, veterinarians must realize there is very little in the literature regarding actual pharmacokinetics and safety. March 10, 2020. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/8527, zoetisus.com/products/cats/revolution-plus. Boy MG, Six RH, Thomas CA, et al. Revolution (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. Ivermectin and selamectin are common oral and topical treatments for these infections, respectively. Do not use in sick, debilitated or underweight animals (see SAFETY). Vatta AF, Young DR, King VL, Myers MR. Tell your veterinarian about all medicines you have given your dog or cat in the past, and any medicines that you are planning to use with Revolution. When the medication invades the system in large enough . This long-acting medication may last up to 4 6 weeks, and may last longer in pets with kidney or liver disease. Vet Dermatol. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Unfortunately it looks like it will in some mammals, namely our pets, and causes the same poisoning as it does to fleas! However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolution because of the emergence of adult fleas from pupae. Selamectin is a member of the macrocyclic lactone class of parasiticides and the chemical name is 25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl--l-arabino- . US Federal law restricts this drug to use by or on the order of a licensed veterinarian. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. McTier TL, Shanks DJ, Watson P, et al. Keep tube compressed on the final squeeze to avoid drawing liquid back into tube. Fisher MA, Shanks DJ. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter. Due to alcohol content, do not apply to broken skin. Avoid contact between Revolution and your fingers. and our Selamectin is an avermectin parasiticide with a variety of labeled uses in dogs and cats. Dr. Patterson completed her small animal rotating internship and small animal internal medicine residency at Texas A&M University and became a diplomate of the American College of Veterinary Internal Medicine (Small Animal Internal Medicine) in 2015. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Its quite expensive, so I wanted to check first. For the control of tick (Dermacentor variabilis) infestations in dogs, Revolution should be administered on a monthly basis. Higher doses were not tested. Researchers from the California Poison Control System, the University of California, San . It also controls roundworms and hookworms in cats. 1. Although commonly thought to be innocuous to both the research animals and any transgenic elements that the animals may carry . Before you use any liquid medication make sure that the color is the same and there are no abnormalities. The efficacy of a topical formulation of selamectin plus sarolaner in preventing the development of a macrocyclic lactone-resistant strain of, Animal Medicinal Drug Use Clarification Act. Independence America Holdings Corp. All Rights Reserved. This being the law and all that. PetPlace may be compensated when you click on or make a purchase using the links in this article. And if you loved saving money (being here at ozbargain) then you wouldn't repeat such emotional tripe. For any additional questions please call our team of experts at 1-800-660-1842. Each of them had their expiration dates extended, on . In November 2018, the FDA approved Revolution Plus (selamectin and sarolaner topical solution; Zoetis, zoetis.com) for use in cats. It is used to kill adult fleas, prevent flea eggs from hatching, prevent and control flea infestations, prevent heartworm disease and treat and control ear mite infestations in dogs and cats. Mealey KL, Bentjen SA, Gay JM, Cantor GH. Do not expose this medication to fire as it is flammable. And get this they're legally enjoined to do so regardless of the manufacturer's expiration dates. There have also been rare reports of seizures in dogs (see WARNINGS). Most of what is known about drug expiration dates comes from a study conducted by the Food and Drug Administration at the request . These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. A kitten, estimated to be 56 weeks old (0.3 kg), died 8 hours after receiving a single treatment of Revolution at the recommended dosage. Do not apply to dogs less than 6 weeks old or cats less than 8 weeks old. If you've been slack with that then you're best not using revolution and get a flea only product before getting a heartworm test on the dog. PetPartners, Inc. is an indirect corporate affiliate of PetPlace.com. And thats a wrap! New York, NY 10017. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It does NOT mean that the product becomes ineffective or useless on that date. Revolution works well in preventing heartworm in cats. That's my take, anyway. Selamectin works by creating an electrolyte imbalance in the nerve and muscle cells of heartworms, which causes paralysis and death. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. Turns out I was right. Selamectin has no such effect in the mammalian nervous system and, therefore, it is considered to be a safe insecticide. So giving such products on your pet will do no good. Longer than 2 years, then Id replace. The Irreverent Veterinarian is a columnist that regularly contributes to PetPlace.com. Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution Topically in accordance with the following tables. What I would suggest is, check the product label carefully before you use the product. 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